Spyre Therapeutics
SYRE · NASDAQ
$91.40+$6.68 (+7.88%)TodayMarket closed ·
Prev close $84.72
Who owns SYRE
Largest institutional holders, from their latest 13F filings
The 10 largest institutions hold 53.2% of SYRE’s shares.
- Fidelity Management & Research Company LLC14.9%
- BlackRock Institutional Trust Company, N.A.6.6%
- Perceptive Advisors LLC5.0%
- RTW Investments L.P.4.9%
- Next 6 largest institutions21.9%
- All other shareholders46.8%
| Holder | Shares | % of shares |
|---|---|---|
| Fidelity Management & Research Company LLC | 12.92M | 14.87% |
| BlackRock Institutional Trust Company, N.A. | 5.72M | 6.59% |
| Perceptive Advisors LLC | 4.32M | 4.97% |
| RTW Investments L.P. | 4.25M | 4.90% |
| Paradigm BioCapital Advisors LP | 3.84M | 4.42% |
| Vanguard Capital Management, LLC | 3.45M | 3.97% |
| State Street Investment Management (US) | 3.06M | 3.52% |
| VR Adviser, LLC | 2.99M | 3.44% |
| T. Rowe Price Associates, Inc. | 2.85M | 3.29% |
| Driehaus Capital Management, LLC | 2.80M | 3.22% |
Largest mutual fund holders
| Holder | Shares | % of shares |
|---|---|---|
| Fidelity Growth Company Fund | 2.67M | 3.07% |
| American Funds SMALLCAP World Fund | 2.56M | 2.95% |
| Vanguard Total Stock Market Index Fund | 2.49M | 2.87% |
| iShares Russell 2000 ETF | 1.92M | 2.21% |
| State Street SPDR S&P Biotech ETF | 1.40M | 1.61% |
Insider trades
Form 4 filings by officers, directors and large holders
Over the last 6 months, insiders sold $438.30M (78 trades) of SYRE on the open market, with no buys.
| Insider | Type | Shares | Value |
|---|---|---|---|
| King-Jones Heidy | Option exercise | 28.93K | — |
| King-Jones Heidy | Sale | 2.60K | $243.00K |
| King-Jones Heidy | Sale | 2.10K | $194.67K |
| King-Jones Heidy | Sale | 7.23K | $660.28K |
| King-Jones Heidy | Sale | 16.61K | $1.50M |
| King-Jones Heidy | Sale | 400 | $35.70K |
| King-Jones Heidy | Option exercise | 28.93K | $419.53K |
| Turtle Cameron | Sale | 100 | $9.39K |
| Turtle Cameron | Sale | 4.99K | $465.92K |
| Turtle Cameron | Sale | 3.99K | $368.22K |
Short interest
Settled Sep 30, 2026
- Shares short
- 12.84M
- Days to cover
- 8.89
- % of shares outstanding
- 14.79%
- Average daily volume
- 1.44M
- Change since last report
- +5.9%
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