Upstream Bio
UPB · NASDAQ
$2.82+$0.02 (+0.71%)TodayMarket closed ·
Prev close $2.80
Who owns UPB
Largest institutional holders, from their latest 13F filings
The 10 largest institutions hold 64.8% of UPB’s shares.
- Fidelity Management & Research Company LLC13.4%
- OrbiMed Advisors, LLC10.5%
- Access Industries, Inc.10.1%
- Norges Bank Investment Management (NBIM)6.9%
- Next 6 largest institutions24.0%
- All other shareholders35.2%
| Holder | Shares | % of shares |
|---|---|---|
| Fidelity Management & Research Company LLC | 7.27M | 13.36% |
| OrbiMed Advisors, LLC | 5.69M | 10.46% |
| Access Industries, Inc. | 5.49M | 10.10% |
| Norges Bank Investment Management (NBIM) | 3.77M | 6.93% |
| Decheng Capital LLC | 2.72M | 5.01% |
| BlackRock Institutional Trust Company, N.A. | 2.65M | 4.86% |
| Enavate Sciences GP, LLC | 2.46M | 4.52% |
| HBM Partners AG | 2.20M | 4.03% |
| Vanguard Capital Management, LLC | 1.88M | 3.45% |
| Millennium Management LLC | 1.14M | 2.10% |
Largest mutual fund holders
| Holder | Shares | % of shares |
|---|---|---|
| Statens Pensjonsfond Utland | 3.77M | 6.93% |
| Vanguard Total Stock Market Index Fund | 1.44M | 2.65% |
| Fidelity Small Cap Growth Fund | 1.37M | 2.52% |
| Fidelity Stock Selector Small Cap Fund | 1.32M | 2.43% |
| Fidelity Series Small Cap Opportunities Fund | 965.80K | 1.77% |
Insider trades
Form 4 filings by officers, directors and large holders
Over the last 6 months, insiders sold $32.81K (6 trades) of UPB on the open market, with no buys.
| Insider | Type | Shares | Value |
|---|---|---|---|
| Deykin Aaron | Sale | 895 | $4.91K |
| Houghton Adam | Sale | 700 | $3.84K |
| Ambrose Allison | Sale | 485 | $2.66K |
| Sutherland Everett Rand | Sale | 2.10K | $11.50K |
| GRAY MICHAEL | Sale | 853 | $4.68K |
| GRAY MICHAEL | Sale | 853 | $5.20K |
| Ruddy Marcella K. | Award | 17.10K | — |
| Fleming Harold Edward | Award | 17.10K | — |
| Chimovits Erez | Award | 17.10K | — |
| Ratcliffe Liam | Award | 17.10K | — |
Short interest
Settled Sep 30, 2026
- Shares short
- 4.51M
- Days to cover
- 7.68
- % of shares outstanding
- 8.30%
- Average daily volume
- 587.97K
- Change since last report
- +0.5%
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