Praxis Precision Medicines
PRAX · NASDAQ
Who owns PRAX
Largest institutional holders, from their latest 13F filings
The 10 largest institutions hold 62.7% of PRAX’s shares.
- Janus Henderson Investors12.3%
- Fidelity Management & Research Company LLC7.7%
- Perceptive Advisors LLC7.3%
- BlackRock Institutional Trust Company, N.A.7.1%
- Next 6 largest institutions28.3%
- All other shareholders37.3%
| Holder | Shares | % of shares |
|---|---|---|
| Janus Henderson Investors | 3.42M | 12.27% |
| Fidelity Management & Research Company LLC | 2.14M | 7.67% |
| Perceptive Advisors LLC | 2.04M | 7.30% |
| BlackRock Institutional Trust Company, N.A. | 1.98M | 7.09% |
| Baker Bros. Advisors LP | 1.75M | 6.29% |
| Orbis Investment Management Ltd. | 1.53M | 5.49% |
| Vanguard Portfolio Management, LLC | 1.34M | 4.79% |
| Vanguard Capital Management, LLC | 1.24M | 4.43% |
| State Street Investment Management (US) | 1.03M | 3.68% |
| Adage Capital Management, L.P. | 1.02M | 3.64% |
Largest mutual fund holders
| Holder | Shares | % of shares |
|---|---|---|
| Vanguard Total Stock Market Index Fund | 888.23K | 3.19% |
| iShares Russell 2000 ETF | 650.90K | 2.33% |
| Vanguard Small-Cap Index Fund | 640.58K | 2.30% |
| State Street SPDR S&P Biotech ETF | 435.77K | 1.56% |
| Fidelity Select Biotechnology Portfolio | 411.43K | 1.48% |
Insider trades
Form 4 filings by officers, directors and large holders
Over the last 6 months, insiders sold $3.61M (12 trades) of PRAX on the open market, with no buys.
| Insider | Type | Shares | Value |
|---|---|---|---|
| Souza Marcio | Gift | 2.60K | — |
| Souza Marcio | Gift | 20.52K | — |
| DeSimone Jill | Option exercise | 3.03K | — |
| DeSimone Jill | Option exercise | 8.57K | — |
| DeSimone Jill | Sale | 837 | $264.25K |
| DeSimone Jill | Sale | 1.28K | $402.76K |
| DeSimone Jill | Sale | 504 | $158.09K |
| DeSimone Jill | Sale | 1.00K | $314.08K |
| DeSimone Jill | Sale | 2.85K | $890.20K |
| DeSimone Jill | Sale | 1.75K | $544.06K |
Congressional trades
Disclosed by members of Congress over the last 12 months
| Member | Type | Amount | Traded |
|---|---|---|---|
| Gilbert CisnerosHouse | Purchase | $1K–$15K | Sep 29, 2026 |
Short interest
Settled Sep 30, 2026
- Shares short
- 4.19M
- Days to cover
- 7.16
- % of shares outstanding
- 15.02%
- Average daily volume
- 585.28K
- Change since last report
- +10.3%
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